July 17, 2024
Insights into the unique biogenesis of human mitoribosomes
The assembly of human mitoribosomes takes place in modules. This surprising result is the outcome of teamwork by CRC members Ricarda Richter-Dennerlein and Henning Urlaub and the MPI Göttingen. Their study provides a detailed overview of the biogenesis of human mitochondrial ribosomes (mitoribosomes) and shows that the biogenesis of these ribosomes is characterized by the formation of protein modules that are then assembled onto ribosomal RNA.
In addition to this comprehensive roadmap, the study highlights their evolutionary divergence from bacterial and cytosolic counterparts and provides an answer to the question of how the coordination of two genomes might occur.
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July 12, 2024
The SFB is getting a new member
Ricarda Richter-Dennerlein has been accepted as a new member of the SFB1565. With her subproject “The interplay of mitochondrial ribosomes and the quality control machinery during ribosome rescue”, she will bring the whole project a decisive step closer to our goal of research. We are looking forward to welcoming her. A warm welcome!
June 20, 2024
Key Function of Antisense Non-Coding RNA as Gene Expression Booster Discovered
Heike Krebber’s team has discovered a previously unanswered question about the occurrence and function of antisense RNA (asRNA). They found that asRNA acts like a booster and accelerates gene expression, especially when the cell has to react quickly and flexibly to changes in the environment. This discovery explains for the first time why cells produce large amounts of asRNA.
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March 1, 2024
High-resolution 3D model of plant RNA polymerase sheds light on photosynthesis
In close collaboration, the team led by Hauke Hillen and Thomas Pfannschmidt has succeeded in creating high-resolution 3D images of the chloroplast copying machine (RNA polymerase PEP) using cryo-electron microscopy. The detailed structure provides new insights into the function and evolution of this cellular machine, which is crucial for the activation of photosynthetic proteins.
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March 1, 2024
Teacher training – Keynote talk by Matthias Dobbelstein
Biology teachers from Lower Saxony exchange ideas to further develop the subject of biology in the upper school.
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February 8, 2024
Mechanistic insights into the ubiquitin labeling system.
Sonja Lorenz and other members of the SFB have succeeded for the first time in visualising the mode of action of a ubiquitin ligase in 3D. The ligase binds ubiquitin molecules to proteins and uses this code to determine whether the proteins are incorporated or degraded, thereby regulating numerous processes in the cell.
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January 30, 2024
It is in our genes – and how our genome folds in 3D
The 3D folding of the genome influences which genes are switched on or off. Marieke Oudelaar and Elisa Oberbeckmann have made a decisive methodological advance in understanding how the genome folds. They succeeded in reproducing chromatin from yeast. This made it possible to systematically analyse the folding process and the proteins involved and to decipher the underlying mechanisms. Their work was funded as part of the Collaborative Research Centre “SFB 1565”.
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December 11, 2023
Marieke Oudelaar member of the SFB1565 has been elected for the EMBO YIP network.
The EMBO Young Investigator Program is an initiative that not only provides financial support to excellent young group leaders in the early stages of their independent careers, but also include travel grants and mentoring opportunities.
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November 13, 2023
Claudia Höbartner Honored for Breakthrough Research in Functional Nucleic Acids
Professor Claudia Höbartner from the University of Würzburg, member of the SFB1565, has been awarded the Hansen Family Award by the Bayer Foundation for her groundbreaking research in functional nucleic acids. The prize, donated by Professor Hansen, former Chairman of the Board of Management and Supervisory Board of Bayer, has been awarded to scientists since 2000.
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