February 8, 2024
Mechanistic insights into the ubiquitin labeling system.
Sonja Lorenz and other members of the SFB have succeeded for the first time in visualising the mode of action of a ubiquitin ligase in 3D. The ligase binds ubiquitin molecules to proteins and uses this code to determine whether the proteins are incorporated or degraded, thereby regulating numerous processes in the cell.