Project P17

About

Posttranslational modifications with ubiquitin and ubiquitin-like modifiers (Ubls) are pivotal regulators of diverse aspects of gene expression. This project focuses on the interplay of the 80S ribosome with components of the Ubl modification machinery, including cryo-EM analyses of catalytic complexes at the ribosome, in-vitro studies of the mechanism and selectivity of ribosome-associated modifications, and the cell-based identification of the pre-requisites thereof.